2-Methoxyethanol → HCID 58795642, compound

Participants

Reaction Steps

To a solution of ethyl 4-(2,2,2-trifluoro-acetylamino)-benzoate (1.58 g, 6.05 mmol, CASRN 24568-14-7) in dry THF was added 2-methoxyethanol (1.192 mL, 15.12 mmol), diisopropyl azodicarboxylate (2.94 mL, 15.12 mmol) and P (3.97 g, 15.12 mmol) and the resulting solution stirred for 4 h. The reaction mixture was concentrated, dissolved in EtOAc, washed sequentially with water and brine, dried (MgSO4), filtered and concentrated. The crude product was purified by SiO2 chromatography eluting with 50% EtOAc/hexane to afford 0.42 g of ethyl 4-(2-methoxy-ethylamino)-benzoate (338).

Provenance & Evidence