Methanesulfonyl chloride → N-(4-aminocyclohexyl)methanesulfonamide hydrochloride

Participants

Reaction Steps

To trans 1,4-diaminocyclohexane (2.0 g, 17.5 mmol) in DCM at 0° C. (ice bath) was added methanesulfonyl chloride (1.63 mL, 21.0 mmol). The reaction was allowed to stir at RT for 1 h when a precipitate formed and was collected on a glass frit, rinsed with DCM, and dried to afford 2.56 g (64%) of 360.

Provenance & Evidence