Divinyl sulfone → HCID 59156653, compound

Participants

Reaction Steps

step 2—A mixture of 380 (0.14 g, 0.39 mmol), 242 (0.19 g, 0.59 mmol), Pd(PPh4 (0.045 g, 0.039 mmol) and Na2CO3 (0.12 g, 1.2 mmol) in DCM-MeOH-toluene (1:2:1, 4 mL) was irradiated in a microwave reactor at 120° C. for 60 min. The reaction mixture was filtered and the filtrate concentrated. The crude product was purified by SiO2 chromatography (DCM/MeOH/NH4OH) followed by preparative HPLC to afford I-266 and I-267.

Provenance & Evidence