Hydrochloric Acid → HCID 68577025, compound

Participants

Reaction Conditions

Reaction Steps

In toluene (5 mL), (R)-2-(4-Chlorophenyl)-1,4-di(2-propenyl)hexahydropyrazine (613 mg, 2.2 mmol) produced in Example 22 was dissolved. To the solution, 28 wt % hydrogen chloride solution in isopropanol (615 mg, 2.2 equivalents) was added, to precipitate crystals. The mixture was stirred at 25° C. for 1 hour. The crystals were separated by filtration under reduced pressure, washed with toluene (5 mL) and dried under vacuum, to obtain 643 mg of the title compound as white crystals (yield: 93%, chemical purity: 92.7 area %). The retention time in the chemical purity analysis method was 7.4 min.

Provenance & Evidence