Methane → HCID 68577138, compound

Participants

Reaction Conditions

Reaction Steps

To (R)-2-(4-chlorophenyl)-4-phenyl-1-(2-propenyl)hexahydropyrazine dihydrochloride (285 mg, 0.87 mmol) produced in Example 21, distilled water (2 mL), conc. hydrochloric acid (181 mg, 2.0 equivalents), ruthenium chloride (9 mg, 0.04 equivalent) and activated charcoal (9 mg) were added. The mixture was stirred at 100° C. for 18 hours. Toluene (4 mL) and 30 wt % aqueous solution of sodium hydroxide (258 mg, 2.2 equivalents) were added thereto. The formed insolubles were removed by filtration, and washed with toluene (2 mL). After the organic layer and aqueous layer of the filtrate were separated, the organic layer was washed twice with distilled water (6 mL). The organic layer was concentrated and dried under vacuum, to obtain 89 mg of the title compound as brown oil (yield: 29%, chemical purity: 83.8 area %). The retention time in the chemical purity analysis method was 3.7 min.

Provenance & Evidence