HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Bromide → 5-Bromoazepan-4-one hydrobromide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | Bromine | HCID 24408 | — |
| Reactant | Azepan-4-one hydrochloride | HCID 22021728 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 5-Bromoazepan-4-one hydrobromide | HCID 22620766 | — |
Reaction Steps
32 mL 62% HBr solution in 50 mL conc. acetic acid was added to 50 g hexahydro-azepin-4-on hydrochloride in 600 mL conc. acetic acid. Then 17.2 mL bromine in 50 mL conc. acetic acid was dropped to the reaction. The solvent was removed and the residue was crystallized from a mixture of DCM/MeOH (8/2) to give 79 g of the desired compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08642774B2 |
| Source dataset | uspto-grants-2014_02 |
| ORD ID | ord-4fc4ac996c1e4153b2ceec3fc966df9f |
| Source note | uspto-grants-2014_02 |