HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Toluenesulfonic acid monohydrate → 2-(1-Benzothiophen-5-yl)malonic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Toluenesulfonic acid monohydrate | HCID 521998 | — |
| Reactant | Di(tert-butyl)2-(1-benzothiophen-5-yl)malonate | HCID 58239411 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 2-(1-Benzothiophen-5-yl)malonic acid | HCID 57615041 | 82.6% |
Reaction Steps
To toluene (2.5 mL) solution of 0.25 g of di(tert-butyl) 2-(1-benzothiophen-5-yl)malonate was added 0.01 g of p-toluenesulfonic acid monohydrate, which was then refluxed for 1 hour. After cooling the reaction mixture, the precipitate was collected by filtration to provide 0.14 g of 2-(1-benzothiophen-5-yl)malonic acid as white solid form.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08273902B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-054bd898c26843d5af008bce44cc61f2 |
| Source note | uspto-grants-2012_09 |