Water → Flupyradifurone

Participants

Reaction Conditions

Reaction Steps

To a suspension of 5 g of sodium 4-(methoxycarbonyl)-5-oxo-2,5-dihydrofuran-3-oxide and 4.2 g of N-[(6-chloropyridin-3-yl)methyl]-2,2-difluoroethylamine in 35 ml of butyronitrile are added, at room temperature, 7.5 g of potassium hydrogensulphate. The mixture is stirred at a temperature of 90° C. for 3 hours. Subsequently, the mixture is cooled to room temperature and admixed with 60 ml of water and 60 ml of dichloromethane. The organic phase is removed and the aqueous phase is extracted twice with 30 ml each time of methylene chloride. The combined organic phases are concentrated to dryness. 5.95 g of 4-[[(6-chloropyridin-3-yl)methyl](2,2-difluoroethyl)amino]furan-2(5H)-one are obtained in a purity of 89% (this corresponds to 91% yield).

Provenance & Evidence