HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2391040Generated: October 30, 2026
Hydroxyamine hydrochloride → Methyl 5-(4-bromophenyl)-3-methylisoxazole-4-carboxylate
https://huagongshe.com/reaction/2391040
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydroxyamine hydrochloride | HCID 443297 | — |
| Reactant | Methyl acetyl(p-bromobenzoyl)acetate | HCID 603116 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | Methyl 5-(4-bromophenyl)-3-methylisoxazole-4-carboxylate | HCID 56604575 | — |
Reaction Steps
2-(4-Bromo-benzoyl)-3-oxo-butyric acid methyl ester (11 g, 39 mmol) and hydroxylamine hydrochloride (2.66 g, 39 mmol) were combined in acetic acid (50 mL), and the reaction was stirred at 115° C. for 1 hour. After cooling, aqueous work-up gave the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08273780B2 |
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| Source dataset | uspto-grants-2012_09 |
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| ORD ID | ord-b0050624c0ce42bfba0fab8f3bddd744 |
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| Source note | uspto-grants-2012_09 |
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