HCID 86686485, compound → HCID 82408854, compound

HRID 239107Notes

Reaction equation

HRID 239107 reaction equation
C([N:8]1[CH2:13][CH2:12][CH:11]([C:14]2[O:15][C:16]([CH3:20])=[C:17]([CH3:19])[N:18]=2)[CH2:10][CH2:9]1)C1C=CC=CC=1.[H][H]>[Pd]>[CH3:19][C:17]1[N:18]=[C:14]([CH:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)[O:15][C:16]=1[CH3:20]

Participants

4

Reactant 2

HCID 86686485HCID 86686485, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 82408854HCID 82408854, compoundYield 111.5%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

1.48 g 1-benzyl-4-(4,5-dimethyl-oxazol-2-yl)-piperidine were stirred at RT for 28 h under 50 psi hydrogen atmosphere and 150 mg palladium charcoal. The mixture was filtered and evaporated to give 1.1 g of the desired product.

Workup

  1. filtrationThe mixture was filtered
  2. customevaporated

Sources & evidence

ORD record
ord-9366b3b5dc564693b341df3d00220f23
Source dataset
uspto-grants-2014_02
Patent number
US08642774B2

Reaction notes

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