Ethyl 1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)cyclopropanecarboxylate → HCID 66660564, compound

HRID 2391095Notes

Reaction equation

HRID 2391095 reaction equation
[F:1][C:2]([F:30])([F:29])[C:3]1[CH:4]=[C:5]([C@H:9]([O:11][C:12](=[O:28])[NH:13][C:14]2[C:15]([CH2:26][CH3:27])=[N:16][O:17][C:18]=2[C:19]2[CH:24]=[CH:23][C:22](Br)=[CH:21][CH:20]=2)[CH3:10])[CH:6]=[CH:7][CH:8]=1.[CH2:31]([O:33][C:34]([C:36]1([C:39]2[CH:44]=[CH:43][C:42](B3OC(C)(C)C(C)(C)O3)=[CH:41][CH:40]=2)[CH2:38][CH2:37]1)=[O:35])[CH3:32]>>[CH2:31]([O:33][C:34]([C:36]1([C:39]2[CH:44]=[CH:43][C:42]([C:22]3[CH:23]=[CH:24][C:19]([C:18]4[O:17][N:16]=[C:15]([CH2:26][CH3:27])[C:14]=4[NH:13][C:12]([O:11][C@@H:9]([C:5]4[CH:6]=[CH:7][CH:8]=[C:3]([C:2]([F:30])([F:29])[F:1])[CH:4]=4)[CH3:10])=[O:28])=[CH:20][CH:21]=3)=[CH:41][CH:40]=2)[CH2:37][CH2:38]1)=[O:35])[CH3:32]

Participants

3

Reactant 2

HCID 53217182Ethyl 1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)cyclopropanecarboxylateHCID 66660521HCID 66660521, compound

Product 1

HCID 66660564HCID 66660564, compound

Procedure

Prepared according to the procedure described in Example 1, Step 6 using [5-(4-bromo-phenyl)-3-ethyl-isoxazol-4-yl]-carbamic acid (R)-1-(3-trifluoromethyl-phenyl)-ethyl ester and 1-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-cyclopropanecarboxylic acid ethyl ester.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-969e634f05884b28b44fda13a3128c55
Source dataset
uspto-grants-2012_09
Patent number
US08273780B2

Reaction notes

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