HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2391096Generated: October 30, 2026
Dimethylformamide → 4-Bromo-2-methoxybenzoyl chloride
https://huagongshe.com/reaction/2391096
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 4-Bromo-2-methoxybenzoic acid | HCID 13450755 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 4-Bromo-2-methoxybenzoyl chloride | HCID 22346782 | — |
Reaction Steps
To a suspension of 4-bromo-2-methoxybenzoic acid (2.5 g, 11.04 mmol) in CHCl3 (20 mL) was added DMF (catalytic) and thionyl chloride (1.6 mL, 22.08 mmol). The reaction was stirred at 55° C. for 1 hour and then concentrated to dryness to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08273780B2 |
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| Source dataset | uspto-grants-2012_09 |
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| ORD ID | ord-8b47489dc57246cf96b26ed6e7971051 |
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| Source note | uspto-grants-2012_09 |
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