HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → 5-(4-Bromophenyl)-1,2-oxazole-4-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | Ethyl 5-(4-bromophenyl)isoxazole-4-carboxylate | HCID 22220993 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Product | 5-(4-Bromophenyl)-1,2-oxazole-4-carboxylic acid | HCID 22831701 | — |
Reaction Steps
5-(4-Bromo-phenyl)-isoxazole-4-carboxylic acid ethyl ester (0.500 g, 1.69 mmol) was dissolved in concentrated hydrochloric acid (2 mL), acetic acid (5 mL), and H2O (5 mL), and the reaction was stirred at 100° C. overnight. The mixture was partitioned between EtOAc and H2O, and the organic layer was separated, dried over MgSO4, filtered, and concentrated to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08273780B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-bae1155603924c8ea866c158fa084018 |
| Source note | uspto-grants-2012_09 |