1-(4-Boronophenyl)cyclopropane-1-carboxylic acid → 1-{4'-[4-((R)-1-Phenyl-ethoxycarbonylamino)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid

Participants

Role	Name	HCID	Charge
Reactant	1-(4-Boronophenyl)cyclopropane-1-carboxylic acid	HCID 46739666	—
Reactant	[5-(4-bromo-phenyl)-isoxazol-4-yl]-carbamic acid (R)-1-phenyl-ethyl ester	HCID 66660307	—
Product	1-{4'-[4-((R)-1-Phenyl-ethoxycarbonylamino)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid	HCID 49838933	—

Reaction Steps

Prepared according to the procedure described in Example 1, Step 6 using [5-(4-bromo-phenyl)-isoxazol-4-yl]-carbamic acid (R)-1-phenyl-ethyl ester and 4-(1-carboxycyclopropyl)phenylboronic acid.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08273780B2
Source dataset	uspto-grants-2012_09
ORD ID	ord-d9b3ea745a4d46349be817084967ef50
Source note	uspto-grants-2012_09