HCID 86686488, compound → HCID 86686489, compound

HRID 239111Notes

Reaction equation

HRID 239111 reaction equation
C([N:8]1[CH2:13][CH2:12][CH:11]([N:14]2[CH2:23][C:22]3[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=3)[N:16]([CH3:24])[C:15]2=[O:25])[CH2:10][CH2:9]1)C1C=CC=CC=1.[H][H]>CO.[Pd]>[CH3:24][N:16]1[C:17]2[C:22](=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH2:23][N:14]([CH:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)[C:15]1=[O:25]

Participants

5

Reactant 2

HCID 86686488HCID 86686488, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 86686489HCID 86686489, compoundYield 63.7%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

2 g palladium charcoal was added to 7.3 g 3-(1-benzyl-piperidin-4-yl)-1-methyl-3,4-dihydro-1H-quinazolin-2-one in 150 mL methanol and stirred for 5 h under 50 psi hydrogen atmosphere. The mixture was filtered and the solvent was removed. Diethylether was added and the precipate was filtered to yield 3.4 g of the desired product.

Workup

  1. filtrationThe mixture was filtered
  2. customthe solvent was removed
  3. additionDiethylether was added
  4. filtrationthe precipate was filtered

Sources & evidence

ORD record
ord-d83819e2c43e4331b5a05cd93aed1feb
Source dataset
uspto-grants-2014_02
Patent number
US08642774B2

Reaction notes

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