Sodium Hydroxide → 1,4-dimethyl-1H-pyrazole-5-carboxylic acid

HRID 2391134Notes

Reaction equation

HRID 2391134 reaction equation
[CH3:1][N:2]1[C:6]([C:7]([O:9]CC)=[O:8])=[C:5]([CH3:12])[CH:4]=[N:3]1.[OH-].[Na+]>C(O)C>[CH3:1][N:2]1[C:6]([C:7]([OH:9])=[O:8])=[C:5]([CH3:12])[CH:4]=[N:3]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 21784699Ethyl 1,4-dimethyl-1H-pyrazole-5-carboxylate

Product 1

HCID 6431501,4-dimethyl-1H-pyrazole-5-carboxylic acidYield 55.4%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Using ethyl 1,4-dimethyl-1H-pyrazole-5-carboxylate (565 mg, 3.36 mmol), 1N aqueous sodium hydroxide solution (4 mL, 4 mmol) and ethanol (4 mL), and by a reaction in the same manner as in Reference Example 20, the title compound (261 mg, 55%) was obtained as colorless crystals.

Workup

  1. customby a reaction in the same manner as in Reference Example 20

Sources & evidence

ORD record
ord-46d97ccf4a1946a6acbfd613f4e7ccb2
Source dataset
uspto-grants-2012_09
Patent number
US08273741B2

Reaction notes

Loading…