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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2391156Generated: October 30, 2026

2-Methyl-2-(3-nitrophenyl)propanenitrile → 2-(3-Aminophenyl)-2-methylpropanenitrile

https://huagongshe.com/reaction/2391156

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Methyl-2-(3-nitrophenyl)propanenitrileHCID 15541324—
CatalystPalladiumHCID 23938—
SolventEthyl AcetateHCID 8857—
Product2-(3-Aminophenyl)-2-methylpropanenitrileHCID 56965787100%

Reaction Steps

To a solution of 2-methyl-2-(3-nitrophenyl)propanenitrile (0.35 g, 1.8 mmol) in ethyl acetate (10 mL) was added 10% palladium/carbon (35 mg), and the mixture was stirred for 10 hr under hydrogen atmosphere. The residual catalyst was filtered through celite, and washed with ethyl acetate. The filtrate was concentrated under reduced pressure to give the title compound (0.35 g, 1.8 mmol) as a pale-yellow oil.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08273741B2
Source datasetuspto-grants-2012_09
ORD IDord-99ea68ded1db490d88aea16a16e7e220
Source noteuspto-grants-2012_09