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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2391157Generated: October 30, 2026

2-Methyl-2-(4-nitrophenyl)propanenitrile → 2-(4-Aminophenyl)-2-methylpropanenitrile

https://huagongshe.com/reaction/2391157

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Methyl-2-(4-nitrophenyl)propanenitrileHCID 823615—
CatalystPalladiumHCID 23938—
SolventEthyl AcetateHCID 8857—
Product2-(4-Aminophenyl)-2-methylpropanenitrileHCID 10057801101.1%

Reaction Steps

To a solution of 2-methyl-2-(4-nitrophenyl)propanenitrile (0.95 g, 5.0 mmol) in ethyl acetate (10 mL) was added 10% palladium/carbon (100 mg), and the mixture was stirred at room temperature for 14 hr under hydrogen atmosphere. The residual catalyst was filtered through celite, and washed with ethyl acetate. The filtrate was concentrated under reduced pressure to give the title compound (0.81 g, 99%) as a pale-yellow oil.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08273741B2
Source datasetuspto-grants-2012_09
ORD IDord-ea329ac8c2014f46869d0eca9f53ebc7
Source noteuspto-grants-2012_09