Sodium Hydroxide → 3-ethoxy-1-methyl-1H-pyrazole-5-carboxylic acid

HRID 2391171Notes

Reaction equation

HRID 2391171 reaction equation
[CH2:1]([O:3][C:4]1[CH:8]=[C:7]([C:9]([O:11]C)=[O:10])[N:6]([CH3:13])[N:5]=1)[CH3:2].[OH-].[Na+]>CO>[CH2:1]([O:3][C:4]1[CH:8]=[C:7]([C:9]([OH:11])=[O:10])[N:6]([CH3:13])[N:5]=1)[CH3:2]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 57441049methyl 3-ethoxy-1-methyl-1H-pyrazole-5-carboxylate

Product 1

HCID 574410503-ethoxy-1-methyl-1H-pyrazole-5-carboxylic acidYield 81%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Using methyl 3-ethoxy-1-methyl-1H-pyrazole-5-carboxylate (2.59 g, 14.1 mmol), methanol (15 mL) and 8N aqueous sodium hydroxide solution (3.00 mL), and in the same manner as in Reference Example 58, the title compound (1.94 g, yield 81%) was obtained.

Sources & evidence

ORD record
ord-d06845afec754edbb2aa969379e122bc
Source dataset
uspto-grants-2012_09
Patent number
US08273741B2

Reaction notes

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