HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 1-(1-Benzyl-4-methyl-piperidin-4-yl)-1,3-dihydro-benzoimidazol-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| Reactant | N-(1-Benzyl-4-methyl-piperidin-4-yl)-benzene-1,2-diamine | HCID 86686490 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-(1-Benzyl-4-methyl-piperidin-4-yl)-1,3-dihydro-benzoimidazol-2-one | HCID 86686492 | 90.4% |
Reaction Steps
A mixture of 121 mg N-(1-benzyl-4-methyl-piperidin-4-yl)-benzene-1,2-diamine and 79 mg CDI in 5 mL dichlormethane was stirred 24 h at RT. Water was added and the mixture was extracted with ethylacetate. The organic layer was concentrated to give 119 mg of the desired product. (M+H)+:322
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08642774B2 |
| Source dataset | uspto-grants-2014_02 |
| ORD ID | ord-3f21ef66e779473999e289c4e9719cdd |
| Source note | uspto-grants-2014_02 |