Oxonium, trimethyl-, tetrafluoroborate(1-) (1:1) → HCID 22617758, compound

HRID 239127Notes

Reaction equation

HRID 239127 reaction equation
F[B-](F)(F)F.[CH3:6][O+](C)C.[C:10]([O:14][C:15]([N:17]1[CH2:23][CH2:22][C:21](=[O:24])[NH:20][CH2:19][CH2:18]1)=[O:16])([CH3:13])([CH3:12])[CH3:11]>ClCCl>[C:10]([O:14][C:15]([N:17]1[CH2:23][CH2:22][C:21]([O:24][CH3:6])=[N:20][CH2:19][CH2:18]1)=[O:16])([CH3:13])([CH3:11])[CH3:12]

Participants

4

Reactant 2

HCID 2735153Oxonium, trimethyl-, tetrafluoroborate(1-) (1:1)HCID 226177365-Oxo-(1,4)diazepane-1-carboxylic acid tert-butyl ester

Product 1

HCID 22617758HCID 22617758, compoundYield 93.9%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

77.5 mg trimethyloxonium tetrafluoroborate was added to 100 mg 5-oxo-[1,4]diazepane-1-carboxylic acid tert-butyl ester in 2 mL dichlormethane at 0-5° C. The reaction mixture was stirred over night at RT. The reaction was washed with saturated sodium hydrogencarbonate solution and water and evaporated to yield 100 mg of the desired product. Rt: 0.79 min (method B), (M+H)+: 229

Workup

  1. washThe reaction was washed with saturated sodium hydrogencarbonate solution and water
  2. customevaporated

Sources & evidence

ORD record
ord-14c337cd01b342b783e1fc2e8373deec
Source dataset
uspto-grants-2014_02
Patent number
US08642774B2

Reaction notes

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