Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1,4-Dioxane hydrochloride → 4-[5-(Propan-2-YL)-1,3,4-oxadiazol-2-YL]piperidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1,4-Dioxane hydrochloride | HCID 20443148 | — |
| 반응물 | 4-(5-Isopropyl-(1,3,4) oxadiazol-2-yl)-piperidine-1-carboxylic acid tert-butyl ester | HCID 70650641 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | 4-[5-(Propan-2-YL)-1,3,4-oxadiazol-2-YL]piperidine | HCID 28344937 | 116.3% |
반응 단계
100 mL saturated dioxane-HCl was added to 16 g 4-(5-isopropyl-(1,3,4) oxadiazol-2-yl)-piperidine-1-carboxylic acid tert-butyl ester in 100 mL dioxane at 0° C. The mixture was stirred at RT for 2 h. The precipitate was filtered and washed with ethyl acetate to give 12.3 g of the desired product.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08642774B2 |
| 출처 데이터셋 | uspto-grants-2014_02 |
| ORD ID | ord-524541ca03804ae0a0e9d4bdc4e86ce6 |
| 출처 메모 | uspto-grants-2014_02 |