Sodium borohydride → HCID 86686043, compound

Participants

Reaction Conditions

Reaction Steps

21.6 g sodium borohydride was added to 130 g 1-benzyl-4-(5-methyl-oxazol-2-yl)-pyridinium in 1.5 L ethanol at 0° C. under nitrogen. The reaction was stirred 30 min at 0° C. and 2 h at RT. The mixture was concentrated and treated with water and ethyl acetate. The organic layer was separated and washed with brine and evaporated. The residue was purified by chromatographie on silica to give 81.2 g of the desired product.

Provenance & Evidence