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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 239136Generated: October 28, 2026

HCID 86686043, compound → HCID 82414136, compound

https://huagongshe.com/reaction/239136

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHCID 86686043HCID 86686043—
CatalystPalladiumHCID 23938—
SolventEthanolHCID 702—
SolventTetrahydrofuranHCID 8028—
ProductHCID 82414136HCID 8241413691.8%

Reaction Steps

25 g 1-benzyl-4-(5-methyl-oxazol-2-yl)-1,2,3,6-tetrahydro-pyridine and 6 g palladium charcoal in 200 mL tetrahydrofuran and 200 mL ethanol were stirred at RT for 12 h under hydrogen atmosphere (30 psi). The mixture was filtered and the filtrate concentrated to yield 15 g of the desired product. Rf: 0.05 (petrolether/ethyl acetate=1/1), (M+H)+: 167

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08642774B2
Source datasetuspto-grants-2014_02
ORD IDord-d51b713c2cb240d5a766bad5c6e20493
Source noteuspto-grants-2014_02