1-Chloroethyl chloroformate → HCID 86686045, compound

Participants

Reaction Steps

20 g 1-chloroethyl chloroformate was added to 24 g 1-benzyl-4-(5-methyl-oxazol-2-yl)-1,2,3,6-tetrahydro-pyridine in 200 mL dichlormethane at 0° C. under nitrogen. After 2 h the solution was concentrated and 200 mL methanol was added. The mixture was refluxed 4 h and concentrated. The residue was crystallized from dichlormethane to give 16 g of the desired product. Rf: 0.02 (petrolether/ethyl acetate=1/1), (M+H)+: 165

Provenance & Evidence