反应详情

15 g 2-chloro-6-nitro-benzaldehyde and 4-amino-1-benzylpiperidine in 150 mL toluol were refluxed for 3 h. The toluol was removed and the residue was dissolved in 300 mL methanol. 6.6 g sodium borohydride was added and the reaction was refluxed over night. The solvent was removed, water and dichlormethane were added and the layers were separated. The organic layer was washed with water, dried and filtered to yield 29 g of the desired product.

1. customThe toluol was removed
2. dissolutionthe residue was dissolved in 300 mL methanol
3. addition6.6 g sodium borohydride was added
4. temperaturethe reaction was refluxed over night
5. customThe solvent was removed
6. additionwater and dichlormethane were added
7. customthe layers were separated
8. washThe organic layer was washed with water
9. customdried
10. filtrationfiltered