HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 18321017, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | tert-Butyl methyl ether | HCID 15413 | — |
| Reactant | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| Reactant | HCID 86686505 | HCID 86686505 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 18321017 | HCID 18321017 | 36.6% |
Reaction Steps
16 g 2-((1-benzyl-piperidin-4-ylamino)-methyl)-3-chloro-phenyl-ammonium and 8.2 g CDI in 150 mL DMF were stirred for 3 h at 60° C. Water and tert.-butyl-methyl-ether were added. The precipitate was filtered to give 6.3 g of the desired product. (M+H)+: 356
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08642774B2 |
| Source dataset | uspto-grants-2014_02 |
| ORD ID | ord-a1a0b5997d7f441dbf0803f0c6fb94bd |
| Source note | uspto-grants-2014_02 |