HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 57505739, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 6-Chloronicotinoyl Chloride | HCID 2782165 | — |
| Reactant | N-{3-[(2-aminoimidazo[1,2-b]pyridazin-6-yl)oxy]phenyl}-3-(trifluoromethyl)benzamide | HCID 57385788 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 57505739 | HCID 57505739 | 77.4% |
Reaction Steps
Using N-{3-[(2-aminoimidazo[1,2-b]pyridazin-6-yl)oxy]phenyl}-3-(trifluoromethyl)benzamide (150 mg, 0.362 mmol), triethylamine (76 μL, 0.544 mmol), 6-chloronicotinoyl chloride (76 mg, 0.435 mmol) and tetrahydrofuran (5 mL) as starting materials and in the same manner as in Example 388, the title compound (155 mg, 77%) was obtained as a pale-yellow powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08273741B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-c139fd8b0e3b4ffe9d8af39ac3708346 |
| Source note | uspto-grants-2012_09 |