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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2391508Generated: October 30, 2026

Triethylamine → HCID 57505739, compound

https://huagongshe.com/reaction/2391508

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTriethylamineHCID 8471—
Reactant6-Chloronicotinoyl ChlorideHCID 2782165—
ReactantN-{3-[(2-aminoimidazo[1,2-b]pyridazin-6-yl)oxy]phenyl}-3-(trifluoromethyl)benzamideHCID 57385788—
SolventTetrahydrofuranHCID 8028—
ProductHCID 57505739HCID 5750573977.4%

Reaction Steps

Using N-{3-[(2-aminoimidazo[1,2-b]pyridazin-6-yl)oxy]phenyl}-3-(trifluoromethyl)benzamide (150 mg, 0.362 mmol), triethylamine (76 μL, 0.544 mmol), 6-chloronicotinoyl chloride (76 mg, 0.435 mmol) and tetrahydrofuran (5 mL) as starting materials and in the same manner as in Example 388, the title compound (155 mg, 77%) was obtained as a pale-yellow powder.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08273741B2
Source datasetuspto-grants-2012_09
ORD IDord-c139fd8b0e3b4ffe9d8af39ac3708346
Source noteuspto-grants-2012_09