Thionyl Chloride → 4-Fluoro-3-methylbenzoyl chloride
Reaction equation
[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](O)=[O:7])=[CH:4][C:3]=1[CH3:11].S(Cl)([Cl:14])=O>>[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([Cl:14])=[O:7])=[CH:4][C:3]=1[CH3:11]Participants
3
Procedure
10 g 4-fluoro-3-methyl-benzoic acid in 150 g thionylchloride was refluxed 1 h. The reaction was evaporated to give 11.2 g desired product.
Workup
- customThe reaction was evaporated
Sources & evidence
- ORD record
- ord-bca7b4f9d8014d21aee8af7e91f4e431
- Source dataset
- uspto-grants-2014_02
- Patent number
- US08642774B2
Reaction notes
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