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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2391528Generated: October 30, 2026

Methyl chloroformate → HCID 57505756, compound

https://huagongshe.com/reaction/2391528

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethyl chloroformateHCID 6586—
ReactantTriethylamineHCID 8471—
ReactantN-{3-[(2-aminoimidazo[1,2-b]pyridazin-6-yl)oxy]phenyl}-3-(trifluoromethyl)benzamideHCID 57385788—
SolventTetrahydrofuranHCID 8028—
ProductHCID 57505756HCID 5750575661%

Reaction Steps

Using N-{3-[(2-aminoimidazo[1,2-b]pyridazin-6-yl)oxy]phenyl}-3-(trifluoromethyl)benzamide (150 mg, 0.362 mmol), methyl chlorocarbonate (33 μL, 0.435 mmol), triethylamine (75 μL, 0.544 mmol) and tetrahydrofuran (3 mL) as starting materials and in the same manner as in Example 388, the title compound (104 mg, 61%) was obtained as a white powder.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08273741B2
Source datasetuspto-grants-2012_09
ORD IDord-687a318742084b8a87731582f28ed1f1
Source noteuspto-grants-2012_09