HCID 86686508, compound → HCID 86686509, compound

Participants

Reaction Steps

200 mg 4-(2-Chloro-6,7-dihydro-thieno[3,2-d]pyrimidin-4-yl)-piperazine-1-carboxylic acid tert-butyl ester and 200 mg Raney-nickel in 20 mL methanol was stirred at 65° C. for 10 h under 4 bar hydrogen atmosphere. The reaction was filtered and the filtrate was evaporated. The residue was purified by HPLC to give 69 mg of the desired product. (M+H)+: 323/324, Rt: 1.58 min (method AD)

Provenance & Evidence