Ammonia → HCID 25152656, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 140 mg of methyl 5-(6-chloro-1H-imidazo[4,5-c]pyridin-1-yl)-3-{[2-(trifluoromethyl)benzyl]oxy}thiophene-2-carboxylate and 20 ml of a saturated solution of ammonia in methanol were stirred in a microwave vial at 120° C. for 4 h in the microwave cavity. The reaction mixture was concentrated to half of the volume. The solid that precipitated after standing was collected and recrystallized from acetonitrile to give the title compound.

Provenance & Evidence