Diethylamine → HCID 25152864, compound

Participants

Reaction Steps

To a solution of 58 mg of [1-(5-carbamoyl-4-{[2-(trifluoromethyl)benzyl]oxy}-2-thienyl)-1H-imidazo[4,5-c]pyridin-6-yl]methyl methanesulfonate (compound A1) in 4 ml of dichloromethane were added 146 mg of diethylamine, and the reaction mixture was stirred at room temperature for 12 h. The mixture was concentrated to dryness under vacuum and the residue was dissolved in acetonitrile/water and purified by preparative HPLC (water/acetonitrile, elution gradient 9/1 to 1/9 (v/v)). After lyophilization the title compound was obtained.

Provenance & Evidence