Cyclopropylamine → HCID 25152865, compound

HRID 2391574Notes

Reaction equation

HRID 2391574 reaction equation
CS(O[CH2:6][C:7]1[N:12]=[CH:11][C:10]2[N:13]=[CH:14][N:15]([C:16]3[S:17][C:18]([C:33](=[O:35])[NH2:34])=[C:19]([O:21][CH2:22][C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=4[C:29]([F:32])([F:31])[F:30])[CH:20]=3)[C:9]=2[CH:8]=1)(=O)=O.[CH:36]1([NH2:39])[CH2:38][CH2:37]1>ClCCl>[CH:36]1([NH:39][CH2:6][C:7]2[N:12]=[CH:11][C:10]3[N:13]=[CH:14][N:15]([C:16]4[S:17][C:18]([C:33]([NH2:34])=[O:35])=[C:19]([O:21][CH2:22][C:23]5[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=5[C:29]([F:30])([F:31])[F:32])[CH:20]=4)[C:9]=3[CH:8]=2)[CH2:38][CH2:37]1

Participants

4

Reactant 2

HCID 69828CyclopropylamineHCID 86647101HCID 86647101, compound2×

Product 1

HCID 25152865HCID 25152865, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

In a similar manner as described for example 6, 58 mg of [1-(5-carbamoyl-4-{[2-(trifluoromethyl)benzyl]oxy}-2-thienyl)-1H-imidazo[4,5-c]pyridin-6-yl]methyl methanesulfonate (compound A1) and 228 mg of cyclopropylamine in 5 ml dichloromethane yield the title compound.

Sources & evidence

ORD record
ord-47efb09029b14d2a910e6c676f6712d9
Source dataset
uspto-grants-2012_09
Patent number
US08273890B2

Reaction notes

Loading…