Ammonia → HCID 25153286, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2.50 g of methyl 5-(1H-imidazo[4,5-b]pyridin-1-yl)-3-{[2-(trifluoromethyl)benzyl]oxy}thiophene-2-carboxylate (compound B5a) and 250 ml of a saturated solution of ammonia in methanol was stirred in an autoclave at 130° C. for 12 h. The reaction mixture was allowed to cool down to room temperature, concentrated, and the resulting residue was purified by flash chromatography (neutral alumina oxide, eluents: ethyl acetate/methanol). After crystallization from acetonitrile the title compound was obtained.

Provenance & Evidence