Trifluoroacetic acid → N-(5,6,7,8-Tetrahydro-4H-thiazolo[4,5-d]azepin-2-yl)-acetamide

Participants

Reaction Steps

35 mL trifluoroacetic acid was added to 2.4 g 2-acetylamino-4,5,7,8-tetrahydro-thiazolo[4,5-d]azepine-6-carboxylic acid tert-butyl ester in 80 mL chloroform. The reaction was stirred 3 h at RT and concentrated. The residue was dissolved in 75 mL chloroform and basified with 2.5 M potassiumcarbonate solution. The chloroform layer was separated and concentrated to give 1.3 g of the desired product. (M+H)+=212

Provenance & Evidence