Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | methyl 5-[6-({[tert-butyl(dimethyl)silyl]oxy}methyl)-1H-imidazo[4,5-c]pyridin-1-yl]-3-[1-(2-chlorophenyl)-2,2,2-trifluoroethoxy]thiophene-2-carboxylate | HCID 68766109 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 68766267 | HCID 68766267 | — |
Reaction Steps
A mixture of 470 mg of methyl 5-[6-({[tert-butyl(dimethyl)silyl]oxy}methyl)-1H-imidazo[4,5-c]pyridin-1-yl]-3-[1-(2-chlorophenyl)-2,2,2-trifluoroethoxy]thiophene-2-carboxylate and 40 ml of a saturated solution of ammonia in methanol is stirred in a microwave vial at 125° C. for 4 h in the microwave cavity. The reaction mixture is concentrated to dryness and the resulting residue is purified by flash chromatography (ethyl acetate/methanol, 90/10 (v/v)) to yield the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08273890B2 |
|---|
| Source dataset | uspto-grants-2012_09 |
|---|
| ORD ID | ord-82c842e54e8945aab7e34773fcacefeb |
|---|
| Source note | uspto-grants-2012_09 |
|---|
