Ammonia → HCID 68764198, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 41 mg of methyl 5-(3H-imidazo[4,5-c]pyridin-3-yl)-3-{[4-(trifluoromethyl)benzyl]oxy}thiophene-2-carboxylate and 5 ml of a saturated solution of ammonia in methanol is stirred in a microwave vial at 125° C. for 4 h in the microwave cavity. The reaction mixture is concentrated to dryness, the resulting residue is dissolved in 5 ml dichloromethane and purified by flash chromatography (dichloromethane/methanol, 95/5 (v/v)) to yield the title compound.

Provenance & Evidence