Ammonia → HCID 68766653, compound

HRID 2391596Notes

Reaction equation

HRID 2391596 reaction equation
[N:1]1[C:9]2[CH:8]=[CH:7][N:6]=[CH:5][C:4]=2[N:3]([C:10]2[S:14][C:13]([C:15]([O:17]C)=O)=[C:12]([O:19][CH2:20][C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=3[O:27][C:28]([F:31])([F:30])[F:29])[CH:11]=2)[CH:2]=1.[NH3:32]>CO>[N:1]1[C:9]2[CH:8]=[CH:7][N:6]=[CH:5][C:4]=2[N:3]([C:10]2[S:14][C:13]([C:15]([NH2:32])=[O:17])=[C:12]([O:19][CH2:20][C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=3[O:27][C:28]([F:30])([F:29])[F:31])[CH:11]=2)[CH:2]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 68765381HCID 68765381, compound

Product 1

HCID 68766653HCID 68766653, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In a similar manner as described for example 28, 57 mg of methyl 5-(3H-imidazo[4,5-c]pyridin-3-yl)-3-{[2-(trifluoromethoxy)benzyl]oxy}thiophene-2-carboxylate and 6 ml of a saturated solution of ammonia in methanol yield the title compound.

Sources & evidence

ORD record
ord-0cc04bf5f4cc405eb0b33a241bc98b31
Source dataset
uspto-grants-2012_09
Patent number
US08273890B2

Reaction notes

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