Ammonia → HCID 68766270, compound

HRID 2391597Notes

Reaction equation

HRID 2391597 reaction equation
[N:1]1[C:9]2[CH:8]=[CH:7][N:6]=[CH:5][C:4]=2[N:3]([C:10]2[S:14][C:13]([C:15]([O:17]C)=O)=[C:12]([O:19][CH2:20][C:21]3[CH:26]=[CH:25][CH:24]=[C:23]([C:27]([F:30])([F:29])[F:28])[CH:22]=3)[CH:11]=2)[CH:2]=1.[NH3:31]>CO>[N:1]1[C:9]2[CH:8]=[CH:7][N:6]=[CH:5][C:4]=2[N:3]([C:10]2[S:14][C:13]([C:15]([NH2:31])=[O:17])=[C:12]([O:19][CH2:20][C:21]3[CH:26]=[CH:25][CH:24]=[C:23]([C:27]([F:28])([F:29])[F:30])[CH:22]=3)[CH:11]=2)[CH:2]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 68766326HCID 68766326, compound

Product 1

HCID 68766270HCID 68766270, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In a similar manner as described for example 28, 65 mg of methyl 5-(3H-imidazo[4,5-c]pyridin-3-yl)-3-{[3-(trifluoromethyl)benzyl]oxy}thiophene-2-carboxylate and 7 ml of a saturated solution of ammonia in methanol yield the title compound.

Sources & evidence

ORD record
ord-3891e2de2b0740918044dda97e1e0e5e
Source dataset
uspto-grants-2012_09
Patent number
US08273890B2

Reaction notes

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