反应详情

温度

125 °C

A mixture of 26.8 mg of methyl 5-(1H-imidazo[4,5-c]pyridin-1-yl)-3-{[2-(trifluoromethoxy)benzyl]oxy}thiophene-2-carboxylate and 5 ml of a saturated solution of ammonia in methanol is stirred in a microwave vial at 125° C. for 4 h in the microwave cavity. The reaction mixture is concentrated to dryness, the resulting residue is dissolved in ethyl acetate and purified by flash chromatography [Silica gel, eluent: ethyl acetate/methanol, elution gradient of 100/0 (v/v) to 95/5 (v/v)] to yield the title compound.

1. concentrationThe reaction mixture is concentrated to dryness
2. dissolutionthe resulting residue is dissolved in ethyl acetate
3. custompurified by flash chromatography [Silica gel, eluent: ethyl acetate/methanol, elution gradient of 100/0 (v/v) to 95/5 (v/v)]