Ammonia → HCID 68768223, compound

HRID 2391605Notes

Reaction equation

HRID 2391605 reaction equation
[C:1]([C:3]1[CH:28]=[CH:27][CH:26]=[CH:25][C:4]=1[CH2:5][O:6][C:7]1[CH:11]=[C:10]([N:12]2[C:20]3[CH:19]=[CH:18][N:17]=[CH:16][C:15]=3[N:14]=[CH:13]2)[S:9][C:8]=1[C:21]([O:23]C)=O)#[N:2].[NH3:29]>CO>[C:1]([C:3]1[CH:28]=[CH:27][CH:26]=[CH:25][C:4]=1[CH2:5][O:6][C:7]1[CH:11]=[C:10]([N:12]2[C:20]3[CH:19]=[CH:18][N:17]=[CH:16][C:15]=3[N:14]=[CH:13]2)[S:9][C:8]=1[C:21]([NH2:29])=[O:23])#[N:2]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 68765021HCID 68765021, compound

Product 1

HCID 68768223HCID 68768223, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In a similar manner as described for example 38, 55 mg of methyl 3-[(2-cyanobenzyl)oxy]-5-(1H-imidazo[4,5-c]pyridin-1-yl)thiophene-2-carboxylate and 20 ml of a saturated solution of ammonia in methanol yield the title compound.

Sources & evidence

ORD record
ord-1f92a8986da54d79a540762f8c922a73
Source dataset
uspto-grants-2012_09
Patent number
US08273890B2

Reaction notes

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