Ammonia → HCID 68770208, compound

HRID 2391609Notes

Reaction equation

HRID 2391609 reaction equation
[Cl:1][C:2]1[CH:27]=[CH:26][CH:25]=[C:24]([Cl:28])[C:3]=1[CH2:4][O:5][C:6]1[CH:10]=[C:9]([N:11]2[C:15]3[CH:16]=[N:17][CH:18]=[CH:19][C:14]=3[N:13]=[CH:12]2)[S:8][C:7]=1[C:20]([O:22]C)=O.[NH3:29]>CO>[Cl:1][C:2]1[CH:27]=[CH:26][CH:25]=[C:24]([Cl:28])[C:3]=1[CH2:4][O:5][C:6]1[CH:10]=[C:9]([N:11]2[C:15]3[CH:16]=[N:17][CH:18]=[CH:19][C:14]=3[N:13]=[CH:12]2)[S:8][C:7]=1[C:20]([NH2:29])=[O:22]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 68765176HCID 68765176, compound

Product 1

HCID 68770208HCID 68770208, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In a similar manner as described for example 38, 123.1 mg of methyl 3-[(2,6-dichlorobenzyl)oxy]-5-(3H-imidazo[4,5-c]pyridin-3-yl)thiophene-2-carboxylate and 15 ml of a saturated solution of ammonia in methanol yield the title compound.

Sources & evidence

ORD record
ord-5bd4510c2c814d97973479819cee1dbd
Source dataset
uspto-grants-2012_09
Patent number
US08273890B2

Reaction notes

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