HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2391618Generated: October 30, 2026
Tetrabutylammonium Fluoride → (1-[2-(difluoromethoxy)phenyl]ethoxy}-5-[6-(hydroxymethyl)-1H-imidazo[4,5-c]pyridin-1-yl]thiophene-2-carboxamide
https://huagongshe.com/reaction/2391618
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Tetrabutylammonium Fluoride | HCID 2724141 | — |
| Reactant | 5-[6-({[tert-butyl(dimethyl)silyl]oxy}methyl)-1H-imidazo[4,5-c]pyridin-1-yl]-3-{-1-[2-(difluoromethoxy)phenyl]ethoxy}thiophene-2-carboxamide | HCID 68767265 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | (1-[2-(difluoromethoxy)phenyl]ethoxy}-5-[6-(hydroxymethyl)-1H-imidazo[4,5-c]pyridin-1-yl]thiophene-2-carboxamide | HCID 86647107 | — |
Reaction Steps
A mixture of 1.44 g of 5-[6-({[tert-butyl(dimethyl)silyl]oxy}methyl)-1H-imidazo[4,5-c]pyridin-1-yl]-3-{-1-[2-(difluoromethoxy)phenyl]ethoxy}thiophene-2-carboxamide in 25 ml THF is cooled to 0° C. At 0° C., 0.91 ml tetra-n-butylammonium fluoride (˜75% in H20) are added. The reaction mixture is allowed to warm to room temperature and stirred for 90 minutes.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08273890B2 |
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| Source dataset | uspto-grants-2012_09 |
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| ORD ID | ord-c237952c4fda4db7a4b8a0c73dac2f1d |
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| Source note | uspto-grants-2012_09 |
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