HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2391623Generated: October 30, 2026
1-(Benzenesulfonyl)piperazine → 5-(6-{[4-(phenylsulfonyl)piperazin-1-yl]methyl}-1H-imidazo[4,5-c]pyridin-1-yl)-3-{(1R)-1-[2-(trifluoromethyl)phenyl]ethoxy}thiophene-2-carboxamide
https://huagongshe.com/reaction/2391623
Participants
| Role | Name | HCID | Charge |
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| Reactant | 1-(Benzenesulfonyl)piperazine | HCID 808712 | — |
| Reactant | [1-(5-carbamoyl-4-{(1R)-1-[2-(trifluoro-methyl)phenyl]ethoxy}-2-thienyl)-1H-imidazo[4,5-c]pyridin-6-yl]methyl methanesulfonate | HCID 86647102 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 5-(6-{[4-(phenylsulfonyl)piperazin-1-yl]methyl}-1H-imidazo[4,5-c]pyridin-1-yl)-3-{(1R)-1-[2-(trifluoromethyl)phenyl]ethoxy}thiophene-2-carboxamide | HCID 68765389 | — |
Reaction Steps
100 mg of [1-(5-carbamoyl-4-{(1R)-1-[2-(trifluoromethyl)phenyl]ethoxy}-2-thienyl)-1H-imidazo[4,5-c]pyridin-6-yl]methyl methanesulfonate are dissolved in 2.5 ml dichloromethane. Under N2 atmosphere benzenesulfonyl piperazine (209 mg) is added. The reaction mixture is stirred at 40° C. for 1 hour and then concentrated to dryness under vacuum. The residue is purified by preparative HPLC (ammonium formate buffer/acetonitrile, elution gradient 97/3 to 0/100 (v/v)) to obtain the title product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08273890B2 |
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| Source dataset | uspto-grants-2012_09 |
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| ORD ID | ord-969a0cb4b7754d90bba2abe83352d23c |
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| Source note | uspto-grants-2012_09 |
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