Triethylamine → (1-{5-carbamoyl-4-[1-(2-chlorophenyl)-2,2,2-trifluoroethoxy]-2-thienyl}-1H-imidazo[4,5-c]pyridin-6-yl)methyl methanesulfonate

Participants

Reaction Steps

In a similar manner as described for example 49 (step 1), 170 mg of 3-[1-(2-chlorophenyl)-2,2,2-trifluoroethoxy]-5-[6-(hydroxymethyl)-1H-imidazo[4,5-c]pyridin-1-yl]thiophene-2-carboxamide, 76.7 mg of methanesulfonyl chloride, and 70.8 mg of triethylamine in 3 ml dichloromethane give (1-{5-carbamoyl-4-[1-(2-chlorophenyl)-2,2,2-trifluoroethoxy]-2-thienyl}-1H-imidazo[4,5-c]pyridin-6-yl)methyl methanesulfonate as crude material that is used for step 2 without further purification.

Provenance & Evidence