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HRID2391627

反应详情

EQUATION

反应方程式

HRID 2391627 的结构方程式

REACTANTS

反应物

2
结构：CC(C)(C)OC(=O)N1C[C@@H]2C[C@H]1CN2
HCID11521263

(1S,4S)-2-BOC-2,5-DIAZABICYCLO[2.2.1]HEPTANE

C10H18N2O2

结构：C[C@@H](Oc1cc(-n2cnc3cnc(COS(C)(=O)=O)cc32)sc1C(N)=O)c1ccccc1C(F)(F)F
HCID86647102

未命名化合物

PRODUCTS

生成物

1
结构：C[C@@H](Oc1cc(-n2cnc3cnc(CN4C[C@@H]5C[C@H]4CN5C(=O)OC(C)(C)C)cc32)sc1C(N)=O)c1ccccc1C(F)(F)F
HCID86647109

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：ClCCl
溶剂HCID6344

Dichloromethane

CH2Cl2

CONDITIONS

反应条件

温度
40 °C

PROCEDURE

实验过程

108 mg of [1-(5-carbamoyl-4-{(1R)-1-[2-(trifluoromethyl)phenyl]ethoxy}-2-thienyl)-1H-imidazo[4,5-c]pyridin-6-yl]methyl methanesulfonate are dissolved in 2.5 ml dichloromethane. Under N2 atmosphere tert-butyl (1S,4S)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate (198 mg) is added. The reaction mixture is stirred at 40° C. for 1 hour and then concentrated to dryness under vacuum. The residue is purified by preparative HPLC (ammonium formate buffer/acetonitrile, elution gradient 97/3 to 0/100 (v/v)) to obtain tert-butyl (1S,4S)-5-{[1-(5-carbamoyl-4-{(1R)-1-[2-(trifluoromethyl)phenyl]ethoxy}-2-thienyl)-1H-imidazo[4,5-c]pyridin-6-yl]methyl}-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate.

WORKUP

后处理

  1. concentrationconcentrated to dryness under vacuum
  2. customThe residue is purified by preparative HPLC (ammonium formate buffer/acetonitrile, elution gradient 97/3 to 0/100 (v/v))