反应详情

7 g 3-oxo-2,3,4,4a, 5,6,8,9-octahydro-1,2,7-triaza-benzocycloheptene-7-carboxylic acid tert-butyl ester was dissolved in 70 mL toluene and 6.7 g manganese dioxide was added to the reaction mixture. It was heated at reflux for 48 h. After completion of the reaction, the reaction mixture was diluted with chloroform and filtered through celite. The filtrate was concentrated and purified by column chromatography to afford 5.5 g of the desired product. (M+H)+=266

1. temperatureIt was heated
2. temperatureat reflux for 48 h
3. customAfter completion of the reaction
4. filtrationfiltered through celite
5. concentrationThe filtrate was concentrated
6. custompurified by column chromatography