Dichloromethane → [1-(5-carbamoyl-4-{[(2-chlorophenyl)propyl]oxy}-2-thienyl)-1H-imidazo[4,5-c]pyridin-6-yl]methyl methanesulfonate

Participants

Reaction Steps

In a similar manner as described for example 49 (step 1), 1 g of 3-{[1-(2-chlorophenyl)propyl]oxy}-5-[6-(hydroxymethyl)-1H-imidazo[4,5-c]pyridin-1-yl]thiophene-2-carboxamide, 517 mg of methanesulfonyl chloride, and 457 mg of triethylamine in 19 ml dichloromethane give [1-(5-carbamoyl-4-{[(2-chlorophenyl)propyl]oxy}-2-thienyl)-1H-imidazo[4,5-c]pyridin-6-yl]methyl methanesulfonate as crude material that is used for step 2 without further purification.

Provenance & Evidence