HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethylamine → 5-{6-[(ethylamino)methyl]-3H-imidazo[4,5-c]pyridin-3-yl}-3-{(1R)-1-[2-(trifluoromethyl)phenyl]ethoxy}thiophene-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethylamine | HCID 6341 | — |
| Reactant | [3-(5-carbamoyl-4-{(1R)-1-[2-(trifluoromethyl)phenyl]ethoxy}-2-thienyl)-3H-imidazo[4,5-c]pyridin-6-yl]methyl methanesulfonate | HCID 86647106 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 5-{6-[(ethylamino)methyl]-3H-imidazo[4,5-c]pyridin-3-yl}-3-{(1R)-1-[2-(trifluoromethyl)phenyl]ethoxy}thiophene-2-carboxamide | HCID 68770174 | — |
Reaction Steps
In a similar manner as described for example 116, 200 mg of crude [3-(5-carbamoyl-4-{(1R)-1-[2-(trifluoromethyl)phenyl]ethoxy}-2-thienyl)-3H-imidazo[4,5-c]pyridin-6-yl]methyl methanesulfonate (example 49, step 1) and 0.925 ml ethylamine (2 M solution in THF) in 4 ml methanol give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08273890B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-b6f541aa7c9847449e81651c371775ef |
| Source note | uspto-grants-2012_09 |